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Blood

Activity 3B: Why Opposites Attract: Blood Agglutination
Topic: Blood

Part of:
Unit: Cast Your Net: Adventures with Blood
Lesson 3: I Want Your Blood: Blood Transfusions

Entire Activity Download (15 pages, 1 MB)

Individual Downloads

Print Friendly (student pages only - 7 pages)

Teacher Background Information

Teacher Administrative Information

Student Directions

Student Antibody Center Template Page

Student Antibody End Template Page

Student Antigen Template Page

Student Red Blood Cell Template Page

Student Data Pages

Keywords

blood, abo blood group, blood group, antigen, red blood cell, blood type, antibody, antibodies, agglutination

Search Curricular Keywords

Key Concepts

Antigens, Glycolipid markers, Cell membrane components, ABO blood groups, Carbohydrates, Rh factor, Components of blood, Antibodies, Agglutination, Blood compatibility

Process Skills Utilized

Organizing information, sequencing events, reading charts, graphs, and tables,
independent research, analyzing data

Intended Grade Level - 6-10

Objectives

Using antigen models, students will be able to:

  • Examine the ABO antigens found on red blood cells and the antibodies that are present in the bloodstream
  • Identify the cause of agglutination as well as the reason why some blood types are able to be mixed
  • Explain reasons for the process of agglutination

Activity Description

In this activity, students will examine how antigens on the surface of red blood cells determine the ABO blood types. Using templates provided in the activity, students will construct models of the antibodies present in A, B, AB, and O blood types. Using the ABO blood antigen models created in Activity 3A “Hey, What's Your Type?” and the antibody models from this activity, students will demonstrate the process of agglutination to enhance their understanding of antibody-antigen reactions.

Activity Materials

  • Antibody Center template (1 copy per group)
  • Antibody End template (5 copies per group)
  • Template Page (2 copies per group)
  • Construction paper
  • Scissors
  • Glue
  • Craft sticks (optional)

Activity Management Suggestions

MODIFICATIONS:
For students needing more assistance: Group these students with peers who can assist them during the activity. Check often for understanding.

For highly able students: Students may also be grouped with other students to provide peer assistance. Students may also work on the extension activities.

Extension

Allow these students to do research on the carbohydrate structures that make up blood sub-types in addition to the ABO and Rh antigens. Students may also do research on how the Rh factor complicates blood type compatibility.

References Used

Daily, JF. (1998). Blood. Arlington: Medical Consulting Group.

Daniels, G. (2002). Human Blood Groups. Malden, MA: Blackwell Science.

Galley, HF. (2002). Blood and Blood Transfusion. London: BMJ Books.

Huestis, D. (1988). Practical Blood Transfusion. Boston: Little, Brown.

Quinley, E. (1998). Immunohematology: Principles and practice. New York: Lippencott.

Reid, M. & Lomas-Francis, C. (1997). The blood group antigen facts book. California: Academic Press.

Roitt, I.; Brostoff, J.; & Male, D. (1998). Immunology: Fifth edition. Philadelphia: Mosby.

Stites, D.; Terr, A. & Parslow, T. (1997). Medical immunology. Stamford, Connecticut: Appleton & Lange.

 

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