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Entire Activity Download (36 pages, 1 MB)
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Keywords chromosome, gene, genome, nucleus
Search Curricular Keywords
Key Concepts
Karyotype, Chromosome
Mapping, Genes,
and Chromosomes
Process Skills Utilized
Making inferences,
synthesizing information
Intended Grade Level - 6-8
Objectives
Using paper chromosomes, students will be able to:
- Identify the parts of a chromosome
- Locate specific genes on human chromosomes
- Demonstrate how traits are encoded in genes found on chromosomes
Activity Description
Working in pairs, students will select a human chromosome and map a few selected genes onto a paper representation of their chromosome. Next, they will use an online database from the Human Genome Project to identify and map 6 additional genes. As a culminating activity, they will create a chromosome model that is exactly 10 times larger than their paper model. The classroom will morph into a huge nucleus from a human cell as the giant chromosomes are placed around the room.
Activity Materials (per group of 2)
- 1 copy of Student Information Page
- Sets of Chromosome Patterns as needed so each pair of students gets 1 chromosome*
- 1 Metric ruler per student
- Scissors
- Colored markers
- Butcher Paper, Craft Foam, Foam Flotation Noodles, Papier mache, or other materials for making the large chromosome models
*For example, if you have 150 students, you will have 75 student pairs working on the activity. Divide the number of student pairs by 24 chromosomes per set and round to the highest number, so you will need 3 sets of chromosomes for all of your classes.
Activity Management Suggestions
Review group skills with students.
Review basic definitions of genes and chromosomes.
Allow students to work in pairs for this activity. Write numbers 1- 22, X and Y on small pieces of paper and allow student pairs to draw a number for their chromosome. Alternately, you can assign a chromosome number to students.
When the large chromosome models are turned in, hang them from the ceiling of the classroom to turn the classroom into a giant human nucleus. Be sure to hang complete sets of 46 chromosomes together! Have students determine whether the “cell” belongs to a male or female.
Unlike other activities, there will be no Student Data Page section in this activity. Students will record all information on the Chromosome Pattern Pages that follow this teacher section.
References Used
Online Mendelian Inheritance in Man website:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=omim
The Human Genome Project at Sanger Centre at the Welcome Trust Genome Campus
http://www.wellcome.ac.uk/doc_WTD002945.html
Chromosomes and Genetic Mapping
http://www.woodrow.org/teachers/bi/1994/chromosomes.html
Human Genome Project
http://www.ornl.gov/sci/techresources/Human_Genome/home.shtml
National Center for Biotechnology Information, National Institutes of Health
http://www.ncbi.nlm.nih.gov/
The Human Gene Map, National Center for Biotechnology Information
http://www.ncbi.nlm.nih.gov/SCIENCE96/chr.cgi?9
Genome News Network Website
http://www.genomenewsnetwork.org/resources/
whats_a_genome/Chp1_1_1.shtml#genome1
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